IBM Sametime Configuration Validator does something very simple yet very useful. It harvests the entire configuration of a Sametime environment and validates the settings against a standard validation profile based on best practices and known settings. What it does is totally deterministic, i.e., total grunt work, and very powerful because now you don't have to do it manually.
The tool generates reports that tell you how the configuration stands against the standard profile and points out potential problems you may encounter. The report doesn't necessarily tell you that there's something wrong with your configuration. But, based on what's known to work, it'll tell you whether something may potentially go awry. That way you can nip any bad mojo in the bud and go back to relaxing.